- Cordarone, Pacerone
- Dosage: 100–200 mg/d
- Formulations: T: 200, 400
- Comments (Metabolism): Most effective antifibrillatory agent; avoid as first-line tx for AF unless patient has HF or substantial LVH; numerous adverse events, including pulmonary and hepatic toxic effects, neurologic and dermatologic adverse events, hypothyroidism, hyperthyroidism, corneal deposits, numerous drug interactions, including warfarin*; very long half-life (weeks) (L)
Notes:
* following a drug name indicates the drug is available as a generic formulation.
BC following a drug name indicates the drug is listed in the 2023 American Geriatrics Society Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults.
K = renal elimination; L = hepatic elimination